Product Certification&
    Enterprise Certification

  • Ms.CEO +8619930501653
    Tel: +8619930501653

  • Ms.Emily
    Tel: +8619930501652

  • Ms.Hedy
    Tel: 15532137863

  • Mobile:+8619930501653
  • Tel:+8619930501653
  • Fax:/
  • URL:
  • Province/state:Hebei
  • City:Shijiazhuang
  • Street:No.66, Yvhua West Road
  • MaxCard:
Home > Products >  Folinic acid supplier factory manufacture with top quality CAS 58-05-9

Folinic acid supplier factory manufacture with top quality CAS 58-05-9 CAS NO.58-05-9

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,T/T,Western Union,MoneyGram,Other
  • Product Details


  • Folinic acid
  • 58-05-9
  • Dopamine hcl

Quick Details

  • ProName: Folinic acid supplier factory manufact...
  • CasNo: 58-05-9
  • Molecular Formula: C20H23N7O7
  • Appearance: white powder
  • Application: Folinic acid is also used in combinati...
  • DeliveryTime: within 7-10 days
  • PackAge: according to your request
  • Port: any port in China
  • ProductionCapacity: 1000 Metric Ton/Month
  • Purity: 99%min
  • Storage: keep in dry and cool
  • Transportation: express, air, sea
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade


folinic acid supplier factory manufacture with top quality cas 58-05-9


product namefolinic acid


mf: c20h23n7o7

mw: 473.44

appearcane: white powder


item name folinic acid 
cas no 58-05-9 
molecular formula c20h23n7o7 
molecular weight 473.44 
function folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and is also used in combination with 5-fluorouracil to treat colorectal cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. 
apparence white powder
package aluminum bag;drums;paper box outside
shipment fedex;dhl;ups;tnt;ems;sea;air.
payment western union;t/t;trade assurance;l/c
warranty 2 years


specification of folinic acid


test items







a white or light yellow, amorphous powder.



ir spectrum exhibits maxima only at the same

wavelengths as the reference standard



related substances



individual impurity



total impurities



specific optical rotation

+13.30 to +18.50º

+16.91 º

heavy metals

nmt 0.005%

< 0.005%

water content

nmt 5.0%



97.0% to 102.0%


applications of folinic acid

folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan,

where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. no apparent effect is seen

on pre-existing methotrexate-induced nephrotoxicity.folinic acid can be taken as a pill (orally) or injected into a vein (intravenously) or muscle 



while not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate

overdose. different dosing protocols are used, but folinic acid should be redosed until the methotrexate level is less than

5 x 10−8 m.


additionally, folinic acid is sometimes used to reduce the side effects of methotrexate in rheumatoid arthritis patients.

this includes reductions in nausea, abdominal pain, abnormal liver blood tests, and mouth sores.


folinic acid is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. in this case, folinic acid is not used for "rescue" purposes; rather, it enhances the 

effect of 5-fluorouracil by inhibiting thymidylate synthase.


folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors

such as trimethoprim and pyrimethamine. it may be prescribed in the treatment of toxoplasmosis retinitis, in combination

with the folic acid antagonists pyrimethamine and sulfadiazine.


folinic acid has dextro- and levorotary isomers, only the latter one being pharmacologically useful. as such, levoleucovorin

was approved by the fda in 2008.


it has been investigated for use in down syndrome, but a benefit has not been demonstrated.


research has suggested a role for folinic acid in the treatment of anxiety and depression in people with a variant of the 

mthfr gene


pictures show of folinic acid




Company Information

Thanks for your considering of Hebei Guanlang Biotechnology Co., Ltd.(Crovell).   Crovell is a fast growing intermediates company,Which located in Shijiazhuang,Hebei Province.


Crovell is specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,such as phenylacetamide, dimethylamine hcl, benzyl chloride etc., Crovell also supply various industrial chemicals for customers, such as citric acid,potassium chloride etc.


After ten years development,Crovell has become a Diversified development company,not only involves in chemicals, but also real estate ,clothes ,agricultural products and so on.


So far, Crovell has business in more than 35 countries,most big customers come from europe and America, because among the suppliers in china,Crovell can always make the product quality best, some of the products from Crovell can reach the purity of 99.9+, such as 2-phenylacetamide. This is the important reason for customers who choosing Crovell.


In future, Crovell must become to a more important trade bridge for china and foreign countries especially in pharmaceutical industries.


Company and factory show




Packing and Shipping


Package details:

1kg/Aluminum foil bag

1kg/ Aluminium Tin


25kg/ Aluminum Drum

Delivery Time: Usually within 2 working days after confirming the payment.

Shipping details:DHL; TNT; UPS or EMS





Our sevice


1. Any inquiries will be replied immediately.

2. Shipment is quickly. Sample order in stock and 3-7 days for bulk production.

3. Quality control, before shipment, free sample for test.

4. Packing as your request, with photo before shipment.

5. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

6. After-sale service is supplied.

   (1) International Authorized Third-Party Test For The Products You Demand.
   (2) 60 Days Warranty of quality of goods.

7. Prompt shipment with professional documents.

8. We offer convenient one-stop purchasing service.





1.   Why we choose you

Ten years’ experience in pharmaceutical and industrial chemicals, crovell knows about the market clearly. Quality and customer’s feedbacks are the most important to crovell.


2.   Can you provide free samples

Of course, for some of the products, free sample is available. You just need to pay for the freight, or you can offer courier account number for sample collect from us.


3.   How long the goods will be sent you

For samples, it will be sent out within 24 hours.

For bulk orders, it usually be sent out about 7-15 days after confirming the order.


4.   What is the payment options

For samples, you can use WU, MG, Bitcoin, TT and so on.

For bulk orders, you can use TT, L/C or DP.


5.   Do you have after-sale service

Of course, we have professional after-service department. Any issues will be solved promptly.



Our market


Other products of this supplier

Other Related Products:1009-14-9 102-97-6 532-32-1 141-78-6 5470-11-1 62-44-2 94-09-7 110-63-4
Friend Links:Hebei Guanlang Biotechnology Co., Ltd.LOOKCHEMGoogleBaidu

lookchemhot product CAS New CAS